삼차원적으로 연결된 미세다공성 구조를 가진 이상인산칼슘 골이식재의 골치유에 관한 조직계측학적 평가
Histomorphometric evaluation of bone healing with fully interconnected microporous biphasic calcium phosphate ceramics in rabbit calvarial defects
이종식, 최석규, 류경호, 박진우, 서조영, 이재목, 장제희, 박광범,
소속 상세정보
이종식 ( Lee Jong-Sik ) - 경북대학교 치의학전문대학원 치주과학교실
최석규 ( Choi Seok-Kyu ) - (주)메가젠
류경호 ( Ryoo Gyeong-Ho ) - (주)메가젠
박진우 ( Park Jin-Woo ) - 경북대학교 치의학전문대학원 치주과학교실
서조영 ( Suh Jo-Young ) - 경북대학교 치의학전문대학원 치주과학교실
이재목 ( Lee Jae-Mok ) - 경북대학교 치의학전문대학원 치주과학교실
장제희 ( Jang Je-Hee ) - 경북대학교 치의학전문대학원 치주과학교실
박광범 ( Park Kwang-Bum ) - (주)메가젠
KMID : 0363020080380020117
Abstract
Purpose: The purpose of this study was to histomorphometrically evaluate the osteoconductivity of a new biphasic calcium phosphate ceramics with fully interconnected microporous structure.
Material and Methods: Osseous defects created in the rabbit calvaria were filled with four different bone graft substitutes. Experimental sites were filled with a new fully interconnected microporous biphasic calcium phosphate with(BCP-2) or without(BCP-1) internal macropore of in diameter. MBCP(Biomatlante, France) and Bio-Oss(Geistlich Pharma, Switzerland) were used as controls in this study. Histomorphometric evaluation was performed at 4 and 8 weeks after surgery.
Result: In histologic evaluation, new bone formation and direct bony contact with the graft particles were observed in all four groups. At 4 weeks, BCP-1(15.5%) and BCP-2(15.5%) groups showed greater amount of newly formed mineralized bone area(NB%) compared to BO(11.4%) and MBCP(10.3%) groups. The amounts of NB% at 8 weeks were greater than those of 4 weeks in all four groups, but there was no statistically significant differences in NB% between the groups.
Conclusion: These results indicate that new bone substitutes, BCP with interconnected microporous structure and with or without internal macroporous structures, have the osteoconductivity comparable to those of commercially available bone substitutes, MBCP and Bio-Oss.
키워드
biphasic calcium phosphate;microporous structure;histomorphometry;osteoconductivity
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